Frederick Research Center (FRC) is the host organization of the project. The role of FRC is the management and overall supervision of the project. It is involved in all work packages of the project. Specifically, it is responsible for the coordination of the consortium activities, the management of the project's budget, the production of financial reports needed and the dissemination of the research results. Additionally, FRC is the leading partner for the conduction of experiments involving the preparation and the physicochemical characterization of all the polymeric materials, the study of the self-assembly behaviour of the produced polymers in order to determine the optimal conditions for micelle formation, the controlled release experiments and the cytotoxicity experiments. FRC also contributes towards the determination of drug effects on cell migration and evaluation of drug internalization by immunofluorescence, in collaboration with the Cyprus Institute of Neurology and Genetics.
The University of Cyprus (UCY) as a participating organization is involved in the characterization of the novel hydrophobic monomers and block copolymers in terms of their composition using Proton nuclear magnetic resonance (1H-NMR). Moreover, UCY hosts experiments for micelle characterization in terms of their size using Atomic Force Microscopy (AFM) and Dynamic Light Scattering (DLS).
The Cyprus Institute of Neurology and Genetics (CING) as a participating organization is involved in performing the Wound Healing Assay using Time-lapsed Microscopy in order to examine the effect of the drug on cell migration. Moreover, CING hosts the immunocytochemistry experiments, using Fluorescence Microscopy, in order to test the nanopolymer internalization through endocytosis.